Pharmazin 1000 in 1 g of the drug contains 1000 IU of active tylosin, which corresponds to the content of 1100 mg of the antibiotic tylosin tartrate. The medicinal product is obtained by chemical synthesis and does not contain components of animal and plant origin, genetically modified products.
This combines the antibiotic with epithelium transferase, which prevents the formation of peptide bonds. The drug is active against gram-positive and gram-negative bacteria (Erysipelothrix rhusiopathiae, Bacteriodes nodosus, Moraxella bovis, Staphylococcus spp., Streptococcus spp., Diplococcus spp., Corynebacterium spp. S., Pasdi. ), as well as mycoplasmas (Mycoplasma gallisepticum, M. hyopneumoniae, M. synoviae, M. meleagridis, M. agalactiae, M. bovigenitalium), chlamydia (Chlamydia spp.) and rickettsiae (Rickettsia spp.). The effect of the drug on mycoplasmas exceeds the effect of most known chemotherapeutic agents.
After oral administration, it is well absorbed by the mucous membrane of the digestive tract, creating bacteriostatic levels in the blood and tissues. In broilers, the maximum concentration in the serum is reached in 2 hours after application. Tylosin penetrates well into all organs and tissues. Metabolized mainly in the liver, excreted mainly in urine and bile, as well as milk and eggs.
Calves (under 3 months of age): treatment of animals with infectious enteritis, pneumonia, mycoplasmosis caused by microorganisms sensitive to tylosin.
Pigs: treatment of animals with dysentery, necrotic enteritis, enzootic bronchopneumonia caused by microorganisms sensitive to tylosin.
Chickens, turkeys: treatment of birds with mycoplasmosis, chronic respiratory diseases, infectious sinusitis, necrotic enteritis caused by microorganisms sensitive to tylosin.
Orally in doses:
calves (under 3 months of age) - 10-20 mg of tylosin per 1 kg of body weight or 11-22 mg of the drug per 1 kg of body weight, twice a day with milk or milk replacer, for 7-14 days;
pigs - 20 mg of tylosin per 1 kg of body weight or 22 mg of the drug per 1 kg of body weight for 10 days for the treatment of pneumonia; 5-10 mg of tylosin per 1 kg of body weight or 5.5-11 mg of the drug per 1 kg of body weight for 7 days for the treatment of ileitis;
turkeys - 75-100 mg of tylosin per 1 kg of body weight or 82.5-100 mg of the drug per 1 kg of body weight, once a day for 3-5 days;
chickens - 75-100 mg of tylosin per 1 kg of body weight or 82.5-100 mg of the drug per 1 kg of body weight, once a day for 3-5 days for the treatment of chronic respiratory diseases; 20 mg of tylosin per 1 kg of body weight or 22 mg of the drug per 1 kg of body weight once a day for 3 days for the treatment of necrotic enteritis.
The water with the drug must be changed every 24 hours.
Do not use in animals with hypersensitivity to tylosin or other macrolides.
Do not use in animals with hepatic impairment.
Do not use in case of resistance of microorganisms to tylosin or cross-resistance to other macrolides.
Do not use in horses because of the risk of appendicitis.
Do not use for 1 week before vaccination or during vaccination with drugs whose effectiveness may be reduced by tylosin.
Do not use concomitantly with lincosamides and minoglycoside antibiotics due to a decrease in the antibacterial effect of tylosin.
Side effects - In pigs, temporary symptoms such as diarrhea, pruritus, erythema, vulvar edema, rectal edema and prolapse may occur. These side effects disappear within 48-72 hours from the start of treatment.
Special precautions for use
The use of the drug is recommended after determining the sensitivity of the pathogen to its action.
Insufficient dosage or insufficient duration of treatment can cause the development of resistance in microorganisms.
Use during pregnancy, lactation, laying
The drug for pregnant animals is used only when the benefits outweigh the risks.
Withdrawal period (withdrawal period)
Slaughter of animals and poultry for meat is allowed in 12 days (calves), 1 day (pigs and chickens) and 2 days (turkeys) after the last application of the drug. The meat obtained before this deadline is disposed of or fed to unproductive animals, depending on the opinion of the veterinarian. Egg consumption without restrictions.
Package from material polyethylene / aluminum / polyethylene on 1,1 kg.
Dry dark, out of reach of children at a temperature of 15 ° C to 30 ° C.
Shelf life - 3 years. Shelf life after first opening the original package - 3 months.
Shelf life after the drug has been dissolved in drinking water (milk or milk replacer) - 24 hours.